PRIMARY HUMAN BRAIN CELLS

FROM CELL SYSTEMS

Fast Track Your Drug Discovery Research & Clinical Trials
with More Relevant Data from Primary Human Brain Cells

Drive your research using more biologically relevant cell biology tools, including primary human brain cells. Whether you are modeling neurological disease mechanisms, investigating the blood-brain barrier or investigating neuronal networks, the benefits to using human tissue and unadulterated primary brain cells is clear.

 

  • Highly Predictive: Bridge the gap from lab to life by using more biologically relevant human brain cells expediting your path towards translational research.
  • Research with Confidence: High viability and functionality of our highly-cited primary brain cells gives you the confidence to move forward with a trusted partner.
  • Reproducibility Is Key: Our large, consistent lots of human primary brain cells are always available for the duration of your entire research program and can drive consistency in the lab and breakthroughs for commercialization models.
  • Useful Applications: Ideal for both 2D and 3D brain cell models and ideal for elevating organoid and spheroid structure insights.
  • Reliable, Fast Shipping: Quick and reliable shipping, both domestically and globally, ensure you have the cells and tissue samples you need—when you need them.

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AnaBios Hepatocyte Medium Kit is a specialized solution designed to facilitate the safe and efficient thawing process of cryopreserved hepatocytes.

Citations

Blast-Induced Injury Responsive Relative Gene Expression of Traumatic Brain Injury Biomarkers in Human Brain Microvascular Endothelial Cells

The study investigates blood-brain barrier (BBB) disruption in traumatic brain injury (TBI) by examining the gene expression of TBI biomarkers and neuronal function-related factors in human brain microvascular cells (HBMVECs) using an in-vitro blast TBI model. The results show significant changes in gene expression in response to TBI, depending on injury intensity and time after injury. This suggests that understanding HBMVEC cell signaling could be crucial in comprehending the interaction between the BBB and TBI pathophysiology, warranting further investigation.

 

PDGFR-β Restores Blood-Brain Barrier Functions in a Mouse Model of Focal Cerebral Ischemia

In a study exploring the mechanisms behind blood-brain barrier (BBB) dysfunction after ischemic injury, researchers found that platelet-derived growth factor receptor beta (PDGFR-β) plays a critical role. When PDGFR-β was knocked out in mice, it led to severe brain edema, neurological deficits, reduced expression of tight junction proteins in the BBB, and disrupted barrier function. However, the addition of transforming growth factor-β (TGF-β) improved BBB integrity. In vitro experiments revealed that PDGFR-β and TGF-β receptor signals together enhanced barrier function. This study suggests that PDGFR-β signaling, in conjunction with TGF-β, could be a promising therapeutic target for restoring BBB integrity following cerebral ischemia.

 

 

 

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