FROM CELL SYSTEMS
FROM CELL SYSTEMS
AnaBios primary human hepatocytes provide the most comprehensive metabolic activity for researchers studying liver function and drug metabolism. Our hepatocytes are carefully isolated and characterized to ensure excellent quality and consistency. AnaBios hepatocytes have demonstrated high viability and functionality, making them an ideal model for predicting drug metabolism and toxicity in humans.
Ameliorative Effect of Phophodiesterase 4 and 5 Inhibitors in Deoxycorticosterone Acetate-Salt Hypertensive Uni-nephrectomized KKA Mice
Researchers from Takeda Pharamceutical published research that showed PDE4 and PDE5 inhibitors may be promising treatments for diabetic neuropathy with hypertension.
Promoter Methylation Confers Kidney-Specific Expression of the Kothlo Gene
The aging suppressor gene Klotho exhibits kidney-specific expression across species. However, the mechanisms underlying this expression remain poorly understood. This study presents in vitro and in vivo evidence indicating that promoter methylation plays a role in restricting Klotho gene expression.
The CombinedeRole of Galactose-Deficient IgA1 and Streptocaccal IgA-Binding M Protein in Inducing IL-6 and C3 Secretion from Human Mesangial Cells: Implications for nephropathy
In this study, IgA nephropathy, characterized by mesangial cell proliferation and immune deposits, the M4 protein from group A streptococcus was found to bind galactose-deficient polymeric IgA1 with high affinity. This binding primarily occurred through the C-terminal region of M4 rather than the IgA-binding region.
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