PRIMARY HUMAN GLOMERULAR CELLS

FROM CELL SYSTEMS

Fast Track Your Drug Discovery & Clinical Trials with More Relevant Data from Primary Human Glomerular Cells

Drive your research using more biologically relevant cell biology tools, including human primary kidney cells. Whether you are modeling kidney disease mechanisms, participating in visual pathway research, or in drug discovery and development, the benefits to using human tissue and unadulterated primary cells is clear.

  • Kidney Disease Research: Human primary glomerular cells are invaluable for studying kidney diseases such as glomerulonephritis and nephrotic syndrome, shedding light on disease mechanisms and potential therapeutic targets.
  • Drug Screening and Testing: These cells play a crucial role in drug screening and testing, allowing researchers to assess the efficacy and safety of potential treatments for kidney disorders.
  • Toxicity Assessment: Human primary glomerular cells enable the evaluation of drug toxicity, ensuring that pharmaceutical compounds do not harm kidney function before advancing to clinical trials.
  • Precision Medicine: Using patient-derived glomerular cells supports precision medicine by tailoring treatments to individual genetic variations and disease profiles, potentially improving treatment outcomes.
  • Glomerular Regeneration: Research involving these cells contributes to the development of regenerative therapies for damaged glomeruli, offering hope for improved kidney function and the treatment of chronic kidney diseases.

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AnaBios Hepatocyte Medium Kit is a specialized solution designed to facilitate the safe and efficient thawing process of cryopreserved hepatocytes.

Citations

Ameliorative Effect of Phophodiesterase 4 and 5 Inhibitors in Deoxycorticosterone Acetate-Salt Hypertensive Uni-nephrectomized KKA Mice

 

Researchers from Takeda Pharamceutical published research that showed PDE4 and PDE5 inhibitors may be promising treatments for diabetic neuropathy with hypertension.

Promoter Methylation Confers Kidney-Specific Expression of the Kothlo Gene

 

The aging suppressor gene Klotho exhibits kidney-specific expression across species. However, the mechanisms underlying this expression remain poorly understood. This study presents in vitro and in vivo evidence indicating that promoter methylation plays a role in restricting Klotho gene expression.

The CombinedeRole of Galactose-Deficient IgA1 and Streptocaccal IgA-Binding M Protein in Inducing IL-6 and C3 Secretion from Human Mesangial Cells: Implications for nephropathy

 

In this study, IgA nephropathy, characterized by mesangial cell proliferation and immune deposits, the M4 protein from group A streptococcus was found to bind galactose-deficient polymeric IgA1 with high affinity. This binding primarily occurred through the C-terminal region of M4 rather than the IgA-binding region.

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