PRIMARY HUMAN LIVER CELLS

FROM CELL SYSTEMS

Fast Track Your Drug Discovery & Clinical Trials with More Relevant Data from Primary Human Liver Cells

Drive your research using more biologically relevant cell biology tools, including human primary liver cells. Whether you are modeling liver disease mechanisms, participating in visual pathway research or in drug discovery and development, the benefits to using human tissue and unadulterated primary liver cells is clear.

 

  • Liver Disease Research: Human primary liver cells are pivotal in studying liver diseases like hepatitis, cirrhosis, and fatty liver disease, providing insights into disease mechanisms and potential treatments.
  • Drug Metabolism Studies: These cells play a crucial role in drug metabolism research, helping to assess how drugs are processed by the liver and their potential impact on liver function.
  • Toxicity Screening: Human primary liver cells are essential for evaluating drug toxicity, ensuring the safety of pharmaceutical compounds before advancing to clinical trials.
  • Personalized Medicine: By using patient-derived liver cells, researchers can tailor drug treatments to individual genetic variations, improving drug efficacy and reducing side effects.
  • Hepatitis and Antiviral Research: They are instrumental in the development of antiviral drugs and therapies for hepatitis, contributing to the fight against viral liver infections and liver transplant success.

 

 

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AnaBios Hepatocyte Medium Kit is a specialized solution designed to facilitate the safe and efficient thawing process of cryopreserved hepatocytes.

Citations

Evaluation of the Utility of the Beta Human Liver Emulation System (BHLES) for CFSAN's RegulatoryToxicology program

The Center for Food Safety and Applied Nutrition collaborated with Emulate to assess the Beta Human Liver Emulation System (BHLES) for regulatory science. Using hepatotoxic and non-toxic compounds, the platform's performance was evaluated based on various parameters, including albumin secretion, urea, LDH release, nuclei number, mitochondrial membrane potential, and apoptosis.

LIF, A Mitogen for Choroidal Endothelial Cells, Protects the Choriocapillaris: Implications for Prevention of Geographic Atrophy

In this paper, leukemia inhibitory factor (LIF), typically known for inhibiting endothelial cell (EC) growth, was found to act as a mitogen for bovine choroidal EC (BCE) but inhibited bovine aortic EC (BAE) growth.

Three-Dimensional Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles

Breast cancer frequently metastasizes to the liver, posing a significant threat. A three-dimensional microfluidic human liver-on-a-chip model was developed to simulate the formation of a premetastatic niche and explore the role of breast cancer-derived extracellular vesicles (EVs) in liver metastasis. The study revealed that breast cancer-derived EVs activate liver sinusoidal endothelial cells (LSECs), triggering endothelial to mesenchymal transition and vessel barrier disruption.

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