PRIMARY HUMAN LIVER CELLS

FROM CELL SYSTEMS

AnaBios is Your Source for High-Quality Human Hepatocytes

AnaBios primary human hepatocytes provide the most comprehensive metabolic activity for researchers studying liver function and drug metabolism. Our hepatocytes are carefully isolated and characterized to ensure excellent quality and consistency. AnaBios hepatocytes have demonstrated high viability and functionality, making them an ideal model for predicting drug metabolism and toxicity in humans. 

 

  • Our tiered qualification process involves multiple stages of testing to ensure superior quality and consistency of hepatocytes across multiple lots.
  • Large hepatocyte lot sizes enable researchers to perform experiments with the same batch of cells for extended periods, reducing experimental variability.
  • Our high cell viability allows for more accurate and reliable prediction of drug metabolism and toxicity in the human liver.
  • Extensive donor information provides researchers with a deeper understanding of the variability in drug metabolism and toxicity responses across different patient populations, enabling the development of more personalized medicine 
  • AnaBios offers fast, reliable shipping for domestic and international orders.

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AnaBios Hepatocyte Medium Kit is a specialized solution designed to facilitate the safe and efficient thawing process of cryopreserved hepatocytes.

Citations

Evaluation of the Utility of the Beta Human Liver Emulation System (BHLES) for CFSAN's RegulatoryToxicology program

The Center for Food Safety and Applied Nutrition collaborated with Emulate to assess the Beta Human Liver Emulation System (BHLES) for regulatory science. Using hepatotoxic and non-toxic compounds, the platform's performance was evaluated based on various parameters, including albumin secretion, urea, LDH release, nuclei number, mitochondrial membrane potential, and apoptosis.

LIF, A Mitogen for Choroidal Endothelial Cells, Protects the Choriocapillaris: Implications for Prevention of Geographic Atrophy

In this paper, leukemia inhibitory factor (LIF), typically known for inhibiting endothelial cell (EC) growth, was found to act as a mitogen for bovine choroidal EC (BCE) but inhibited bovine aortic EC (BAE) growth.

Three-Dimensional Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles

Breast cancer frequently metastasizes to the liver, posing a significant threat. A three-dimensional microfluidic human liver-on-a-chip model was developed to simulate the formation of a premetastatic niche and explore the role of breast cancer-derived extracellular vesicles (EVs) in liver metastasis. The study revealed that breast cancer-derived EVs activate liver sinusoidal endothelial cells (LSECs), triggering endothelial to mesenchymal transition and vessel barrier disruption.

Acceptance of Cell Systems cells as documented by placement of an order for Cell Systems products by an authorized representative constitutes knowledge, understanding, and binding acceptance of all binding restrictions on behalf of the recipient institution or enterprise.