FROM CELL SYSTEMS
FROM CELL SYSTEMS
AnaBios primary human hepatocytes provide the most comprehensive metabolic activity for researchers studying liver function and drug metabolism. Our hepatocytes are carefully isolated and characterized to ensure excellent quality and consistency. AnaBios hepatocytes have demonstrated high viability and functionality, making them an ideal model for predicting drug metabolism and toxicity in humans.
Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction
In vitro and in vivo experiments demonstrated that erianin effectively suppressed angiogenesis in retinal endothelial cells and zebrafish models. The study suggests that erianin's regulation of the RhoA/ROCK1 signaling pathway, influenced by α2 and β1 integrin-collagen interactions, may hold therapeutic promise for intraocular collagen-mediated retinal angiogenesis.
Axl Is Essential for in-vitro Angiogenesis Induced by Vitreous From Patients With Proliferative Diabetic Retinopathy
Elevated levels of growth arrest-specific protein 6 (Gas6), a ligand for the receptor tyrosine kinase Axl, were found in the vitreous of patients with proliferative diabetic retinopathy (PDR). Axl activation was observed in fibrovascular membranes from PDR patients. Inhibition of Axl in cultured retinal endothelial cells blocked PDR vitreous-induced Akt activation, proliferation, migration, and tube formation, suggesting that Axl plays a crucial role in PDR development and could be a promising therapeutic target.
The Long Non-Coding RNA HOTAIR Is a Critical Epigenetic Mediator of Angiogenesis in Diabetic Retinopathy
This study focuses on the role of HOX antisense intergenic RNA (HOTAIR) in diabetic retinopathy (DR). Elevated HOTAIR levels were observed in retinal endothelial cells exposed to high glucose levels, and this correlated with increased angiogenesis, oxidative stress, and mitochondrial dysfunction. HOTAIR was also found to be upregulated in the retinas of diabetic animals and in the vitreous humor and serum of patients with proliferative DR. Knockdown of HOTAIR protected against glucose-induced changes and appeared to modulate epigenetic pathways. These findings suggest that HOTAIR may be a critical factor in the pathogenesis of DR, with potential diagnostic and therapeutic implications.
Acceptance of Cell Systems cells as documented by placement of an order for Cell Systems products by an authorized representative constitutes knowledge, understanding, and binding acceptance of all binding restrictions on behalf of the recipient institution or enterprise.