PRIMARY HUMAN RETINAL CELLS

FROM CELL SYSTEMS

AnaBios is Your Source for High-Quality Human Hepatocytes

AnaBios primary human hepatocytes provide the most comprehensive metabolic activity for researchers studying liver function and drug metabolism. Our hepatocytes are carefully isolated and characterized to ensure excellent quality and consistency. AnaBios hepatocytes have demonstrated high viability and functionality, making them an ideal model for predicting drug metabolism and toxicity in humans. 

 

  • Our tiered qualification process involves multiple stages of testing to ensure superior quality and consistency of hepatocytes across multiple lots.
  • Large hepatocyte lot sizes enable researchers to perform experiments with the same batch of cells for extended periods, reducing experimental variability.
  • Our high cell viability allows for more accurate and reliable prediction of drug metabolism and toxicity in the human liver.
  • Extensive donor information provides researchers with a deeper understanding of the variability in drug metabolism and toxicity responses across different patient populations, enabling the development of more personalized medicine 
  • AnaBios offers fast, reliable shipping for domestic and international orders.

OPTIMIZE YOUR
EXPERIMENTS

AnaBios Hepatocyte Medium Kit is a specialized solution designed to facilitate the safe and efficient thawing process of cryopreserved hepatocytes.

Citations

Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction

In vitro and in vivo experiments demonstrated that erianin effectively suppressed angiogenesis in retinal endothelial cells and zebrafish models. The study suggests that erianin's regulation of the RhoA/ROCK1 signaling pathway, influenced by α2 and β1 integrin-collagen interactions, may hold therapeutic promise for intraocular collagen-mediated retinal angiogenesis.

Axl Is Essential for in-vitro Angiogenesis Induced by Vitreous From Patients With Proliferative Diabetic Retinopathy

Elevated levels of growth arrest-specific protein 6 (Gas6), a ligand for the receptor tyrosine kinase Axl, were found in the vitreous of patients with proliferative diabetic retinopathy (PDR). Axl activation was observed in fibrovascular membranes from PDR patients. Inhibition of Axl in cultured retinal endothelial cells blocked PDR vitreous-induced Akt activation, proliferation, migration, and tube formation, suggesting that Axl plays a crucial role in PDR development and could be a promising therapeutic target.

The Long Non-Coding RNA HOTAIR Is a Critical Epigenetic Mediator of Angiogenesis in Diabetic Retinopathy

This study focuses on the role of HOX antisense intergenic RNA (HOTAIR) in diabetic retinopathy (DR). Elevated HOTAIR levels were observed in retinal endothelial cells exposed to high glucose levels, and this correlated with increased angiogenesis, oxidative stress, and mitochondrial dysfunction. HOTAIR was also found to be upregulated in the retinas of diabetic animals and in the vitreous humor and serum of patients with proliferative DR. Knockdown of HOTAIR protected against glucose-induced changes and appeared to modulate epigenetic pathways. These findings suggest that HOTAIR may be a critical factor in the pathogenesis of DR, with potential diagnostic and therapeutic implications.

Acceptance of Cell Systems cells as documented by placement of an order for Cell Systems products by an authorized representative constitutes knowledge, understanding, and binding acceptance of all binding restrictions on behalf of the recipient institution or enterprise.