PRIMARY HUMAN RETINAL CELLS

FROM CELL SYSTEMS

Fast Track Your Drug Discovery & Clinical Trials with More Relevant Data from Primary Human Retinal Cells

Drive your research using more biologically relevant cell biology tools, including human primary retinal cells. Whether you are modeling retinal disease mechanisms, participating in visual pathway research, or in drug discovery and development, the benefits to using human tissue and unadulterated primary cells is clear.

 

  • Disease Modeling: Human primary retinal cells serve as a valuable tool for accurately modeling retinal diseases, enabling researchers to study disease mechanisms and test potential drug candidates.
  • Drug Efficacy Testing: These cells facilitate rigorous testing of drug efficacy, allowing researchers to identify promising treatments for conditions like age-related macular degeneration and diabetic retinopathy.
  • Toxicity Assessment: Human primary retinal cells enable the assessment of drug toxicity, ensuring the safety of potential therapies before they progress to clinical trials.
  • Personalized Medicine: Utilizing patient-derived retinal cells supports personalized medicine approaches, tailoring treatments to individual genetic variations and disease profiles.
  • Vision Restoration Research: Research involving human retinal cells contributes to the development of novel therapies aimed at restoring vision in patients with degenerative eye conditions, offering hope for improved quality of life.

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Citations

Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction

In vitro and in vivo experiments demonstrated that erianin effectively suppressed angiogenesis in retinal endothelial cells and zebrafish models. The study suggests that erianin's regulation of the RhoA/ROCK1 signaling pathway, influenced by α2 and β1 integrin-collagen interactions, may hold therapeutic promise for intraocular collagen-mediated retinal angiogenesis.

Axl Is Essential for in-vitro Angiogenesis Induced by Vitreous From Patients With Proliferative Diabetic Retinopathy

Elevated levels of growth arrest-specific protein 6 (Gas6), a ligand for the receptor tyrosine kinase Axl, were found in the vitreous of patients with proliferative diabetic retinopathy (PDR). Axl activation was observed in fibrovascular membranes from PDR patients. Inhibition of Axl in cultured retinal endothelial cells blocked PDR vitreous-induced Akt activation, proliferation, migration, and tube formation, suggesting that Axl plays a crucial role in PDR development and could be a promising therapeutic target.

The Long Non-Coding RNA HOTAIR Is a Critical Epigenetic Mediator of Angiogenesis in Diabetic Retinopathy

This study focuses on the role of HOX antisense intergenic RNA (HOTAIR) in diabetic retinopathy (DR). Elevated HOTAIR levels were observed in retinal endothelial cells exposed to high glucose levels, and this correlated with increased angiogenesis, oxidative stress, and mitochondrial dysfunction. HOTAIR was also found to be upregulated in the retinas of diabetic animals and in the vitreous humor and serum of patients with proliferative DR. Knockdown of HOTAIR protected against glucose-induced changes and appeared to modulate epigenetic pathways. These findings suggest that HOTAIR may be a critical factor in the pathogenesis of DR, with potential diagnostic and therapeutic implications.

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