Organ-on-a-chips made from human primary cells have been gaining popularity in recent years as a potential research model. Not only do these systems contribute to the replacement, reduction, and refinement of animal experiments, they have also shown promises for more biologically relevant results for toxicology and drug discovery. In the paper, "Utilization of a model hepatotoxic compound, diglycolic acid, to evaluate liver Organ-Chip performance and in vitro to in vivo concordance", the Food and Drug Administration and Emulate collaborated to assess the performance of Liver-Chips made from human hepatocytes and Cell Systems' liver sinusoidal endothelial cells (ACBRI 566). These Liver Chips...
Transporting therapeutic drugs and agents across the blood-brain barrier (BBB) has always been a challenge for brain disease therapy. This study examines the permeability of 2D graphene nanosheets through the BBB using a popular in vitro BBB monolayer model constructed with Cell Systems primary human brain microvascular endothelial cells or hBMECs (Cat# ACBRI 376).
Research on the COVID-19 virus is uncovering the virus may, in some cases, be attacking endothelial cells and potentially causing systemic inflammation. This paper titled "Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke" showcases research that utilized our human primary brain microvascular endothelial cells (ACBRI 376). Cell Systems offers a wide variety of human primary endothelial cells that are isolated without the use of antibodies. Our cells are more biologically relevant and offer outstanding consistency and quality for your research programs. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256621/pdf/main.pdf #endothelialcells #covid19 #coronavirus #cellsystems
The COVID-19 pandemic has upended much of the global economy. While most individual's lives have been disrupted, we are still seeing tremendous progress in the scientific community to research this virus and ultimately create a vaccine. As a provider of primary cells to researchers around the world, Cell Systems is ready to ship cells, media and reagents to enable valuable research to continue. Though the insights surrounding this virus are still in the early stage, there has been some interesting papers surrounding COVID-19 and vascular biology -- particularly endothelial cells, including this one in The Lancet. Cell Systems has a large...