Cell Systems News — Organ-on-a-chip
3D modeling of the blood-brain barrier in a microfluidic chip using Cell Systems human primary cells has shed light onto how different types of brain cells can independently affect the brain’s response to neuroinflammation. As a more physiologically relevant model, this BBB-chip can be a new promising tool for understanding the brain.
Organ-on-a-chips made from human primary cells have been gaining popularity in recent years as a potential research model. Not only do these systems contribute to the replacement, reduction, and refinement of animal experiments, they have also shown promises for more biologically relevant results for toxicology and drug discovery. In the paper, "Utilization of a model hepatotoxic compound, diglycolic acid, to evaluate liver Organ-Chip performance and in vitro to in vivo concordance", the Food and Drug Administration and Emulate collaborated to assess the performance of Liver-Chips made from human hepatocytes and Cell Systems' liver sinusoidal endothelial cells (ACBRI 566). These Liver Chips...