Cell Systems News — ACBRI 376

Turn good experiments into great ones. In this article, we share best practices on choosing the right endothelial cells, selecting assay-appropriate media and coatings, and optimizing seeding density to improve reproducibility and translational impact.

3D modeling of the blood-brain barrier in a microfluidic chip using Cell Systems human primary cells has shed light onto how different types of brain cells can independently affect the brain’s response to neuroinflammation. As a more physiologically relevant model, this BBB-chip can be a new promising tool for understanding the brain.   

Transporting therapeutic drugs and agents across the blood-brain barrier (BBB) has always been a challenge for brain disease therapy. This study examines the permeability of 2D graphene nanosheets through the BBB using a popular in vitro BBB monolayer model constructed with Cell Systems primary human brain microvascular endothelial cells or hBMECs (Cat# ACBRI 376).

Research on the COVID-19 virus is uncovering the virus may, in some cases, be attacking endothelial cells and potentially causing systemic inflammation. This paper titled "Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke" showcases research that utilized our human primary brain microvascular endothelial cells (ACBRI 376). Cell Systems offers a wide variety of human primary endothelial cells that are isolated without the use of antibodies. Our cells are more biologically relevant and offer outstanding consistency and quality for your research programs.    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256621/pdf/main.pdf #endothelialcells #covid19 #coronavirus #cellsystems