Since 1989, Cell Systems has supplied primary human cells isolated directly from normal tissue to researchers worldwide.
Explore our high-purity primary human cells below.
Powering translational science with primary human cells
Why Cell Systems primary human cells?
Cell Systems specializes in primary human cells and the precisely matched media and reagents that support them. Our cells are isolated exclusively from normal, site‑specific human tissue, without the use of antibodies, and validated through rigorous functional characterization. Researchers rely on these primary cells for a wide range of applications, including 3D culture, flow cytometry, and next‑generation sequencing.
Key Features:
- Early passage cells, Passage 3 (<12 population doublings)
- Antibody-free isolation
- High viability (~85%), 1M cells per vial
- ~1M cells per vial, exceeding industry average, custom counts available on request
- Supports 2D/3D culture, organ-on-chip, and co-culture
- Shipped as frozen vials or proliferating flasks
- Free reserved lot program with a single donor lot and deep inventory, for consistency across long-term studies
Since 1989, Cell Systems has been laser-focused on developing the highest-standard primary human cells, together with the matched media and reagents that keep them performing.
Isolated from normal human tissue without antibodies and cited across peer-reviewed research, our cells deliver high viability, high cell count, and consistent results, vial after vial.
~85%
viability
~1M
cells per vial
Free reserved lot
program
35+ years of
consistency
Explore our primary human cell catalog
Characterization data, donor details, and citations are listed on every product page.
- ALL
- EYE
- BRAIN
- LIVER
- KIDNEY
- LUNG
- HEART
- DERMAL
- OTHER
Cell Systems’ primary human retinal microvascular endothelial cells (HRMECs, ACBRI 181) and retinal pericytes (ACBRI 183) are optimized for blood-retinal barrier (BRB) modeling, angiogenesis, and retinal microvascular research applications.
These early passage, antibody-free cells are validated in high-impact studies for expression of key endothelial markers including CD31, VEGF, Ang-2, CCL2, NG2, and relevant regulatory RNAs. Applications include retinal permeability modeling, barrier function assays, transendothelial resistance testing, and 3D microvascular-on-chip studies.
With proven performance in co-culture, permeability, and gene expression assays, these primary human cells are ideal for 2D/3D research culture systems, organ-on-chip platforms, and blood-retinal barrier studies.
Cell Systems’ primary human brain microvascular endothelial cells (ACBRI 376) and brain pericytes (ACBRI 498) are optimized for BBB modeling, drug transport, and neurovascular research.
These high-viability, early passage cells are isolated without antibody selection and validated across multiple peer-reviewed studies for expression of key markers including CD31, VEGF, IL-6, and miR-296.
With proven performance in co-culture, angiogenesis, inflammation, and gene expression assays, they’re ideal for 2D/3D culture, organ-on-chip, and brain cell platforms.
Cell Systems' primary human liver sinusoidal microvascular endothelial cells (ACBRI 566) are optimized for liver-on-chip modeling, drug-induced liver injury research, and hepatic vascular biology.
These cells are validated across multiple peer-reviewed studies spanning liver microphysiological systems, FDA regulatory toxicology programs, and endothelial coagulation research.
With proven performance in quad-culture liver-chip platforms alongside hepatocytes, Kupffer cells, and stellate cells, they're ideal for 2D/3D culture, organ-on-chip, and hepatic toxicology applications.
Cell Systems’ primary human glomerular microvascular endothelial cells (ACBRI 128) and glomerular mesangial cells (ACBRI 127) are optimized for glomerular barrier models, renal endothelial cell culture, and kidney-on-chip research.
These early passage, antibody-free cells are validated in peer-reviewed studies for expression of key markers such as CD31, CD105, Annexin V, ICAM1, and GLP-1R. Applications include glomerular endothelial cell culture, apoptosis assays, transendothelial signaling studies, and integration into glomerulus chip systems.
With demonstrated performance in inflammation, cell–cell signaling, gene expression, and barrier integrity assays, these human glomerular endothelial cells and mesangial cells are ideal for 2D/3D glomerular cell culture, renal disease modeling, and microvascular chip development.
Cell Systems' primary human lung microvascular endothelial cells (ACBRI 468) and lung fibroblast cells (ACBRI 469) are optimized for pulmonary barrier models, lung stromal-vascular research, and lung-on-chip systems.
ACBRI 468 is validated in peer-reviewed studies for expression of key markers including CD62E (E-Selectin), VWF/Factor VIII, and DiI-Ac-LDL uptake. Applications include acute lung injury drug screening, metastatic niche formation, and endothelial metabolic assays, while ACBRI 469 supports extracellular matrix production, fibrotic remodeling, and stromal coculture applications.
With demonstrated performance in calcium signaling, barrier integrity, protein aggregation, and mitochondrial function assays, these human lung endothelial and fibroblast cells are ideal for 2D/3D lung cell culture, pulmonary disease modeling, and lung-on-chip development.
Connect with Our Experts
Reach out to discuss how we can support your research, or visit us at Cell Bio 2026 this December, booth 1117.